A multifunctional biomimetic hybrid nanocarrier for the controlled delivery of chemotherapy drugs by near-infrared light

Xinyu Cui; Wenlong Cheng; Mingdong Dong; Xiaojun Han

doi:10.1039/C8NJ05879B

A multifunctional biomimetic hybrid nanocarrier for the controlled delivery of chemotherapy drugs by near-infrared light

Xinyu Cui
, Wenlong Cheng
, Mingdong Dong^*
, Xiaojun Han

^*Corresponding author for this work

School of Chemistry and Chemical Engineering, Harbin Institute of Technology
Monash University
Aarhus University

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

Controlled drug release is a promising technique that is used in the treatment of cancer. Herein, drug nanocarriers were developed based on Fe₃O₄@mSiO₂ (mesoporous silica-coated Fe₃O₄) nanoparticles (NPs) gated by a lipid bilayer. The nanocarriers exhibited near-infrared (NIR) light-stimulated drug release in a remote and stepwise pattern. Mesoporous silica surrounds Fe₃O₄ NPs and ensures high drug capacity and easy modification of the lipid bilayer. Heat generated from the Fe₃O₄ NPs upon NIR irradiations increases the permeability of the lipid bilayer, which in turn causes drug release. Based on in vitro experiment results, DOX-loaded nanocarriers exhibited the highest cell death percentage of 75.7% with NIR laser irradiation for 5 min at the doxorubicin (DOX) dose of 10 μg mL⁻¹. Because of the flexible and precise control of NIR laser, the nanocarriers have great potential in cancer treatment.

Original language	English
Pages (from-to)	2752-2757
Number of pages	6
Journal	New Journal of Chemistry
Volume	43
Issue number	6
DOIs	https://doi.org/10.1039/C8NJ05879B
State	Published - 2019
Externally published	Yes

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This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.1039/C8NJ05879B

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title = "A multifunctional biomimetic hybrid nanocarrier for the controlled delivery of chemotherapy drugs by near-infrared light",

abstract = "Controlled drug release is a promising technique that is used in the treatment of cancer. Herein, drug nanocarriers were developed based on Fe3O4@mSiO2 (mesoporous silica-coated Fe3O4) nanoparticles (NPs) gated by a lipid bilayer. The nanocarriers exhibited near-infrared (NIR) light-stimulated drug release in a remote and stepwise pattern. Mesoporous silica surrounds Fe3O4 NPs and ensures high drug capacity and easy modification of the lipid bilayer. Heat generated from the Fe3O4 NPs upon NIR irradiations increases the permeability of the lipid bilayer, which in turn causes drug release. Based on in vitro experiment results, DOX-loaded nanocarriers exhibited the highest cell death percentage of 75.7\% with NIR laser irradiation for 5 min at the doxorubicin (DOX) dose of 10 μg mL−1. Because of the flexible and precise control of NIR laser, the nanocarriers have great potential in cancer treatment.",

author = "Xinyu Cui and Wenlong Cheng and Mingdong Dong and Xiaojun Han",

note = "Publisher Copyright: {\textcopyright} The Royal Society of Chemistry and the Centre National de la Recherche Scientifique.",

year = "2019",

doi = "10.1039/C8NJ05879B",

language = "英语",

volume = "43",

pages = "2752--2757",

journal = "New Journal of Chemistry",

issn = "1144-0546",

publisher = "Royal Society of Chemistry",

number = "6",

}

TY - JOUR

T1 - A multifunctional biomimetic hybrid nanocarrier for the controlled delivery of chemotherapy drugs by near-infrared light

AU - Cui, Xinyu

AU - Cheng, Wenlong

AU - Dong, Mingdong

AU - Han, Xiaojun

PY - 2019

Y1 - 2019

N2 - Controlled drug release is a promising technique that is used in the treatment of cancer. Herein, drug nanocarriers were developed based on Fe3O4@mSiO2 (mesoporous silica-coated Fe3O4) nanoparticles (NPs) gated by a lipid bilayer. The nanocarriers exhibited near-infrared (NIR) light-stimulated drug release in a remote and stepwise pattern. Mesoporous silica surrounds Fe3O4 NPs and ensures high drug capacity and easy modification of the lipid bilayer. Heat generated from the Fe3O4 NPs upon NIR irradiations increases the permeability of the lipid bilayer, which in turn causes drug release. Based on in vitro experiment results, DOX-loaded nanocarriers exhibited the highest cell death percentage of 75.7% with NIR laser irradiation for 5 min at the doxorubicin (DOX) dose of 10 μg mL−1. Because of the flexible and precise control of NIR laser, the nanocarriers have great potential in cancer treatment.

AB - Controlled drug release is a promising technique that is used in the treatment of cancer. Herein, drug nanocarriers were developed based on Fe3O4@mSiO2 (mesoporous silica-coated Fe3O4) nanoparticles (NPs) gated by a lipid bilayer. The nanocarriers exhibited near-infrared (NIR) light-stimulated drug release in a remote and stepwise pattern. Mesoporous silica surrounds Fe3O4 NPs and ensures high drug capacity and easy modification of the lipid bilayer. Heat generated from the Fe3O4 NPs upon NIR irradiations increases the permeability of the lipid bilayer, which in turn causes drug release. Based on in vitro experiment results, DOX-loaded nanocarriers exhibited the highest cell death percentage of 75.7% with NIR laser irradiation for 5 min at the doxorubicin (DOX) dose of 10 μg mL−1. Because of the flexible and precise control of NIR laser, the nanocarriers have great potential in cancer treatment.

UR - https://www.scopus.com/pages/publications/85061188723

U2 - 10.1039/C8NJ05879B

DO - 10.1039/C8NJ05879B

M3 - 文章

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SN - 1144-0546

VL - 43

SP - 2752

EP - 2757

JO - New Journal of Chemistry

JF - New Journal of Chemistry

IS - 6

ER -

A multifunctional biomimetic hybrid nanocarrier for the controlled delivery of chemotherapy drugs by near-infrared light

Abstract

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