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A Mechanically Flexible Aptamer-Based Graphene Nanosensor for Biomarker Monitoring

  • Ziran Wang*
  • , Zhuang Hao
  • , Xuezeng Zhao
  • , Qiao Lin
  • *Corresponding author for this work
  • Columbia University
  • Harbin Institute of Technology

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

This paper presents an aptamer-based graphene field-effect transistor nanosensor, which is fabricated on an ultrathin polyethylene terephthalate film towards the real-time and specific monitoring of biomarkers in biofluids. The nanosensor offers a consistent transconductance, carrier mobility and on/off ratio when undergoing large bending deformations. When coated with a nonionic surfactant, the graphene conducting channel also enables the effective suppression of nonspecific binding. The ultrathin nanosensor is tested on specific and reliable real-time monitoring of TNF-α in artificial tears, demonstrating its potential in wearable medical applications and clinical diagnosis.

Original languageEnglish
Title of host publication2019 20th International Conference on Solid-State Sensors, Actuators and Microsystems and Eurosensors XXXIII, TRANSDUCERS 2019 and EUROSENSORS XXXIII
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages2428-2431
Number of pages4
ISBN (Electronic)9781728120072
DOIs
StatePublished - Jun 2019
Event20th International Conference on Solid-State Sensors, Actuators and Microsystems and Eurosensors XXXIII, TRANSDUCERS 2019 and EUROSENSORS XXXIII - Berlin, Germany
Duration: 23 Jun 201927 Jun 2019

Publication series

Name2019 20th International Conference on Solid-State Sensors, Actuators and Microsystems and Eurosensors XXXIII, TRANSDUCERS 2019 and EUROSENSORS XXXIII

Conference

Conference20th International Conference on Solid-State Sensors, Actuators and Microsystems and Eurosensors XXXIII, TRANSDUCERS 2019 and EUROSENSORS XXXIII
Country/TerritoryGermany
CityBerlin
Period23/06/1927/06/19

Keywords

  • Aptamer
  • affinity sensor
  • biomarker
  • field-effect transistor
  • flexible electronics
  • graphene
  • wearable sensors

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