A dual functional AEE fluorogen as a mitochondrial-specific bioprobe and an effective photosensitizer for photodynamic therapy

Engui Zhao; Haiqin Deng; Sijie Chen; Yuning Hong; Chris Wai Tung Leung; Jacky Wing Yip Lam; Ben Zhong Tang

doi:10.1039/c4cc07128j

A dual functional AEE fluorogen as a mitochondrial-specific bioprobe and an effective photosensitizer for photodynamic therapy

Engui Zhao
, Haiqin Deng
, Sijie Chen
, Yuning Hong
, Chris Wai Tung Leung
, Jacky Wing Yip Lam
, Ben Zhong Tang^*

^*Corresponding author for this work

Hong Kong University of Science and Technology
University of Melbourne
South China University of Technology

Research output: Contribution to journal › Article › peer-review

82 Scopus citations

Abstract

We report a dual functional aggregation-enhanced emission (AEE) molecule, TPE-IQ, which could target and illuminate mitochondria in both live and fixed cells with superb selectivity and high signal-to-noise ratio. More intriguingly, TPE-IQ can serve as a photosensitizer to generate reactive oxygen species (ROS) in the mitochondria region to induce cell apoptosis.

Original language	English
Pages (from-to)	14451-14454
Number of pages	4
Journal	Chemical Communications
Volume	50
Issue number	92
DOIs	https://doi.org/10.1039/c4cc07128j
State	Published - 23 Oct 2014
Externally published	Yes

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10.1039/c4cc07128j

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abstract = "We report a dual functional aggregation-enhanced emission (AEE) molecule, TPE-IQ, which could target and illuminate mitochondria in both live and fixed cells with superb selectivity and high signal-to-noise ratio. More intriguingly, TPE-IQ can serve as a photosensitizer to generate reactive oxygen species (ROS) in the mitochondria region to induce cell apoptosis.",

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AU - Zhao, Engui

AU - Deng, Haiqin

AU - Chen, Sijie

AU - Hong, Yuning

AU - Leung, Chris Wai Tung

AU - Lam, Jacky Wing Yip

AU - Tang, Ben Zhong

PY - 2014/10/23

Y1 - 2014/10/23

N2 - We report a dual functional aggregation-enhanced emission (AEE) molecule, TPE-IQ, which could target and illuminate mitochondria in both live and fixed cells with superb selectivity and high signal-to-noise ratio. More intriguingly, TPE-IQ can serve as a photosensitizer to generate reactive oxygen species (ROS) in the mitochondria region to induce cell apoptosis.

AB - We report a dual functional aggregation-enhanced emission (AEE) molecule, TPE-IQ, which could target and illuminate mitochondria in both live and fixed cells with superb selectivity and high signal-to-noise ratio. More intriguingly, TPE-IQ can serve as a photosensitizer to generate reactive oxygen species (ROS) in the mitochondria region to induce cell apoptosis.

UR - https://www.scopus.com/pages/publications/84908431958

U2 - 10.1039/c4cc07128j

DO - 10.1039/c4cc07128j

M3 - 文章

C2 - 25302466

AN - SCOPUS:84908431958

SN - 1359-7345

VL - 50

SP - 14451

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JO - Chemical Communications

JF - Chemical Communications

IS - 92

ER -

A dual functional AEE fluorogen as a mitochondrial-specific bioprobe and an effective photosensitizer for photodynamic therapy

Abstract

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