A cyanine-derived near-infrared molecular rotor for ratiometric imaging of mitochondrial viscosity in cells

Xueluer Mu; Yang Liu; Shengsen Liu; Yilin Sun; Nana Lu; Yingxi Lu; Weiqi Li; Xianfeng Zhou; Bin Liu; Zhibo Li

doi:10.1016/j.snb.2019.126831

A cyanine-derived near-infrared molecular rotor for ratiometric imaging of mitochondrial viscosity in cells

Xueluer Mu
, Yang Liu
, Shengsen Liu
, Yilin Sun
, Nana Lu
, Yingxi Lu
, Weiqi Li
, Xianfeng Zhou^*
, Bin Liu
, Zhibo Li

^*Corresponding author for this work

School of Physics

Qingdao University of Science and Technology
School of Chemistry and Chemical Engineering, Harbin Institute of Technology
University of Akron
Shenzhen University

Research output: Contribution to journal › Article › peer-review

50 Scopus citations

Abstract

We developed a new cyanine-derived near-infrared (NIR) molecular rotor Mu1, which is superior to the traditional cyanines with high viscosity response, large Stokes shift (˜100 nm), and high photo-stability to detect the microscopic viscosity ratiometrically. The time-dependent density functional theory calculations highlighted the structure-optical properties of Mu1 as molecular rotor. Due to the mitochondria-actived fluorescence characteristics, Mu1 was used to track mitochondrial viscosity changes in live cells with high spatial and temporal resolution. This new type of NIR molecular rotor presented herein may open up new opportunities of NIR sensors for biomedical diagnosis and imaging applications.

Original language	English
Article number	126831
Journal	Sensors and Actuators B: Chemical
Volume	298
DOIs	https://doi.org/10.1016/j.snb.2019.126831
State	Published - 1 Nov 2019

Keywords

Cyanine-derived
Mitochondrial viscosity
Molecular rotor
Near-infrared fluorescence
Ratiometric sensing

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10.1016/j.snb.2019.126831

Cite this

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title = "A cyanine-derived near-infrared molecular rotor for ratiometric imaging of mitochondrial viscosity in cells",

abstract = "We developed a new cyanine-derived near-infrared (NIR) molecular rotor Mu1, which is superior to the traditional cyanines with high viscosity response, large Stokes shift (˜100 nm), and high photo-stability to detect the microscopic viscosity ratiometrically. The time-dependent density functional theory calculations highlighted the structure-optical properties of Mu1 as molecular rotor. Due to the mitochondria-actived fluorescence characteristics, Mu1 was used to track mitochondrial viscosity changes in live cells with high spatial and temporal resolution. This new type of NIR molecular rotor presented herein may open up new opportunities of NIR sensors for biomedical diagnosis and imaging applications.",

keywords = "Cyanine-derived, Mitochondrial viscosity, Molecular rotor, Near-infrared fluorescence, Ratiometric sensing",

author = "Xueluer Mu and Yang Liu and Shengsen Liu and Yilin Sun and Nana Lu and Yingxi Lu and Weiqi Li and Xianfeng Zhou and Bin Liu and Zhibo Li",

note = "Publisher Copyright: {\textcopyright} 2019 Elsevier B.V.",

year = "2019",

month = nov,

day = "1",

doi = "10.1016/j.snb.2019.126831",

language = "英语",

volume = "298",

journal = "Sensors and Actuators B: Chemical",

issn = "0925-4005",

publisher = "Elsevier B.V.",

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TY - JOUR

T1 - A cyanine-derived near-infrared molecular rotor for ratiometric imaging of mitochondrial viscosity in cells

AU - Mu, Xueluer

AU - Liu, Yang

AU - Liu, Shengsen

AU - Sun, Yilin

AU - Lu, Nana

AU - Lu, Yingxi

AU - Li, Weiqi

AU - Zhou, Xianfeng

AU - Liu, Bin

AU - Li, Zhibo

PY - 2019/11/1

Y1 - 2019/11/1

N2 - We developed a new cyanine-derived near-infrared (NIR) molecular rotor Mu1, which is superior to the traditional cyanines with high viscosity response, large Stokes shift (˜100 nm), and high photo-stability to detect the microscopic viscosity ratiometrically. The time-dependent density functional theory calculations highlighted the structure-optical properties of Mu1 as molecular rotor. Due to the mitochondria-actived fluorescence characteristics, Mu1 was used to track mitochondrial viscosity changes in live cells with high spatial and temporal resolution. This new type of NIR molecular rotor presented herein may open up new opportunities of NIR sensors for biomedical diagnosis and imaging applications.

AB - We developed a new cyanine-derived near-infrared (NIR) molecular rotor Mu1, which is superior to the traditional cyanines with high viscosity response, large Stokes shift (˜100 nm), and high photo-stability to detect the microscopic viscosity ratiometrically. The time-dependent density functional theory calculations highlighted the structure-optical properties of Mu1 as molecular rotor. Due to the mitochondria-actived fluorescence characteristics, Mu1 was used to track mitochondrial viscosity changes in live cells with high spatial and temporal resolution. This new type of NIR molecular rotor presented herein may open up new opportunities of NIR sensors for biomedical diagnosis and imaging applications.

KW - Cyanine-derived

KW - Mitochondrial viscosity

KW - Molecular rotor

KW - Near-infrared fluorescence

KW - Ratiometric sensing

UR - https://www.scopus.com/pages/publications/85069704634

U2 - 10.1016/j.snb.2019.126831

DO - 10.1016/j.snb.2019.126831

M3 - 文章

AN - SCOPUS:85069704634

SN - 0925-4005

VL - 298

JO - Sensors and Actuators B: Chemical

JF - Sensors and Actuators B: Chemical

M1 - 126831

ER -

A cyanine-derived near-infrared molecular rotor for ratiometric imaging of mitochondrial viscosity in cells

Abstract

Keywords

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