黑木耳多糖顺铂配合物抗 HeLa 和 LoVo 细胞增殖活性

Junqiang Qiu; Jingnan Miao; Hua Zhang; Shumin Liu

doi:10.13748/j.cnki.issn1007-7693.2019.14.001

黑木耳多糖顺铂配合物抗 HeLa 和 LoVo 细胞增殖活性

Translated title of the contribution: Antiproliferative Activity of Auricularia Auricula Polysaccharide-cis-diaminedichloroplatinum Complex Against HeLa and LoVo Cell

Junqiang Qiu
, Jingnan Miao
, Hua Zhang
, Shumin Liu

Hainan Medical University
School of Chemistry and Chemical Engineering, Harbin Institute of Technology
Heilongjiang University of Traditional Chinese Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

OBJECTIVE To study whether Auricularia auricula polysaccharide(AAP) can form complexes with cisplatin, and study the anti-tumor cell proliferation activity of the complexes against HeLa and LoVo cells. METHODS Auricularia auricula polysaccharide-cis-diaminedichloroplatinum(AAP-CDDP) complexes with different molecular weights were synthesized using “One pot” method, and their anti-tumor cell proliferation activity in vitro were studied by MTT method. RESULTS The inhibition activity of AAP-CDDP on the proliferation of HeLa and LoVo cervical cancer cells was closely related to the amount of cisplatin in AAP-CDDP, and the correlation coefficients of r² were 0.877 5 and 0.913 2, respectively. Among them, AAP(V)-CDDP had the strongest anti-tumor cell proliferation activity. CONCLUSION The complex of AAP and cisplatin has good anti-tumor cell proliferation activity.

Translated title of the contribution	Antiproliferative Activity of Auricularia Auricula Polysaccharide-cis-diaminedichloroplatinum Complex Against HeLa and LoVo Cell
Original language	Chinese (Traditional)
Pages (from-to)	1729-1732
Number of pages	4
Journal	Chinese Journal of Modern Applied Pharmacy
Volume	36
Issue number	14
DOIs	https://doi.org/10.13748/j.cnki.issn1007-7693.2019.14.001
State	Published - Jul 2019
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.13748/j.cnki.issn1007-7693.2019.14.001

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@article{a790f2d66c044ac4b29f663b00ea441a,

title = "黑木耳多糖顺铂配合物抗 HeLa 和 LoVo 细胞增殖活性",

abstract = "OBJECTIVE To study whether Auricularia auricula polysaccharide(AAP) can form complexes with cisplatin, and study the anti-tumor cell proliferation activity of the complexes against HeLa and LoVo cells. METHODS Auricularia auricula polysaccharide-cis-diaminedichloroplatinum(AAP-CDDP) complexes with different molecular weights were synthesized using “One pot” method, and their anti-tumor cell proliferation activity in vitro were studied by MTT method. RESULTS The inhibition activity of AAP-CDDP on the proliferation of HeLa and LoVo cervical cancer cells was closely related to the amount of cisplatin in AAP-CDDP, and the correlation coefficients of r2 were 0.877 5 and 0.913 2, respectively. Among them, AAP(V)-CDDP had the strongest anti-tumor cell proliferation activity. CONCLUSION The complex of AAP and cisplatin has good anti-tumor cell proliferation activity.",

keywords = "Auricularia auricula polysaccharide, CDDP, anti-tumor, complex",

author = "Junqiang Qiu and Jingnan Miao and Hua Zhang and Shumin Liu",

year = "2019",

month = jul,

doi = "10.13748/j.cnki.issn1007-7693.2019.14.001",

language = "繁体中文",

volume = "36",

pages = "1729--1732",

journal = "Chinese Journal of Modern Applied Pharmacy",

issn = "1007-7693",

publisher = "Chinese Journal of Modern Applied Pharmacy Publishing House ",

number = "14",

}

TY - JOUR

T1 - 黑木耳多糖顺铂配合物抗 HeLa 和 LoVo 细胞增殖活性

AU - Qiu, Junqiang

AU - Miao, Jingnan

AU - Zhang, Hua

AU - Liu, Shumin

PY - 2019/7

Y1 - 2019/7

N2 - OBJECTIVE To study whether Auricularia auricula polysaccharide(AAP) can form complexes with cisplatin, and study the anti-tumor cell proliferation activity of the complexes against HeLa and LoVo cells. METHODS Auricularia auricula polysaccharide-cis-diaminedichloroplatinum(AAP-CDDP) complexes with different molecular weights were synthesized using “One pot” method, and their anti-tumor cell proliferation activity in vitro were studied by MTT method. RESULTS The inhibition activity of AAP-CDDP on the proliferation of HeLa and LoVo cervical cancer cells was closely related to the amount of cisplatin in AAP-CDDP, and the correlation coefficients of r2 were 0.877 5 and 0.913 2, respectively. Among them, AAP(V)-CDDP had the strongest anti-tumor cell proliferation activity. CONCLUSION The complex of AAP and cisplatin has good anti-tumor cell proliferation activity.

AB - OBJECTIVE To study whether Auricularia auricula polysaccharide(AAP) can form complexes with cisplatin, and study the anti-tumor cell proliferation activity of the complexes against HeLa and LoVo cells. METHODS Auricularia auricula polysaccharide-cis-diaminedichloroplatinum(AAP-CDDP) complexes with different molecular weights were synthesized using “One pot” method, and their anti-tumor cell proliferation activity in vitro were studied by MTT method. RESULTS The inhibition activity of AAP-CDDP on the proliferation of HeLa and LoVo cervical cancer cells was closely related to the amount of cisplatin in AAP-CDDP, and the correlation coefficients of r2 were 0.877 5 and 0.913 2, respectively. Among them, AAP(V)-CDDP had the strongest anti-tumor cell proliferation activity. CONCLUSION The complex of AAP and cisplatin has good anti-tumor cell proliferation activity.

KW - Auricularia auricula polysaccharide

KW - CDDP

KW - anti-tumor

KW - complex

UR - https://www.scopus.com/pages/publications/85181091771

U2 - 10.13748/j.cnki.issn1007-7693.2019.14.001

DO - 10.13748/j.cnki.issn1007-7693.2019.14.001

M3 - 文章

AN - SCOPUS:85181091771

SN - 1007-7693

VL - 36

SP - 1729

EP - 1732

JO - Chinese Journal of Modern Applied Pharmacy

JF - Chinese Journal of Modern Applied Pharmacy

IS - 14

ER -

黑木耳多糖顺铂配合物抗 HeLa 和 LoVo 细胞增殖活性

Abstract

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