表皮生长因子受体突变的肺腺癌转化为小细胞肺癌患者特点探索

Objective To explore the clinicopathological characteristics and genomic characteristics of four patients with epidermal growth factor receptor(EGFR)‑mutated advanced adenocarcinoma transformed into small‑cell lung cancer. Methods Four cases of EGFR‑mutated advanced adenocarcinoma of the lung transformed into small‑cell lung cancer were studied by clinical data, pathological morphology, immunohistochemistry and gene detection. Result EGFR‑mutated adenocarcinoma of the lung was heterogeneous in clinical and genomic profiles, of ten characterized by RB1, TP53 and PIK3CA mutations. Its transformation into small‑cell lung cancer was a particularly aggressive mechanism of drug resistance, but the machanisms were not clear NSE and other tumor indicators had low diagnostic value for transformation. Conclusions EGFR‑mutated adenocarcinoma of the lung transformed into small‑cell lung cancer was one of the reasons for EGFR resistance with avery poor prognosis.