牛初乳中抗高血压因子对成年大鼠心肌细胞电压依懒性钙通道的影响

Gang Teng; Haowei Ren; Tianyu Zhao; Jiaqi Shang; Ning Liu

doi:10.16429/j.1009-7848.2021.03.012

牛初乳中抗高血压因子对成年大鼠心肌细胞电压依懒性钙通道的影响

Translated title of the contribution: The Effect of Anti-hypertension Factor in Bovine Colostrums on Intracellular Voltage Dependent Calcium Channel in Adult Rat Ventricular Myocytes

Gang Teng
, Haowei Ren
, Tianyu Zhao
, Jiaqi Shang
, Ning Liu^*

^*Corresponding author for this work

Northeast Agricultural University

Research output: Contribution to journal › Article › peer-review

Abstract

Objective: To observe the effect of anti-hypertensive factor(AFBC) in bovine colostrum on the intracellular free calcium concentration ([Ca²⁺]_i) induced by potassium chloride in adult rat cardiomyocytes, the possible mechanism of inhibiting myocardial contraction in rats was investigated. Methods: Using fluorescent properties Fura-2/AM at freshly isolated rat ventricular myocytes. Results: 0.5 mg/mL AFBC had no significant effect on resting myocardisl cells [Ca²⁺]_i, but could depress the increase of ventricular myocytes [Ca²⁺]_i induced by 50 mmol/L KCl. Conclusion: AFBC can block the voltage-dependent calcium channel of ventricular myocytes in adult rat.

Translated title of the contribution	The Effect of Anti-hypertension Factor in Bovine Colostrums on Intracellular Voltage Dependent Calcium Channel in Adult Rat Ventricular Myocytes
Original language	Chinese (Traditional)
Pages (from-to)	102-106
Number of pages	5
Journal	Journal of Chinese Institute of Food Science and Technology
Volume	21
Issue number	3
DOIs	https://doi.org/10.16429/j.1009-7848.2021.03.012
State	Published - 31 Mar 2021
Externally published	Yes

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title = "牛初乳中抗高血压因子对成年大鼠心肌细胞电压依懒性钙通道的影响",

abstract = "Objective: To observe the effect of anti-hypertensive factor(AFBC) in bovine colostrum on the intracellular free calcium concentration ([Ca2+]i) induced by potassium chloride in adult rat cardiomyocytes, the possible mechanism of inhibiting myocardial contraction in rats was investigated. Methods: Using fluorescent properties Fura-2/AM at freshly isolated rat ventricular myocytes. Results: 0.5 mg/mL AFBC had no significant effect on resting myocardisl cells [Ca2+]i, but could depress the increase of ventricular myocytes [Ca2+]i induced by 50 mmol/L KCl. Conclusion: AFBC can block the voltage-dependent calcium channel of ventricular myocytes in adult rat.",

keywords = "Antihypertensive, Bovine colostrums, Fura-2/AM, Ventricular myocytes, [Ca]",

author = "Gang Teng and Haowei Ren and Tianyu Zhao and Jiaqi Shang and Ning Liu",

year = "2021",

month = mar,

day = "31",

doi = "10.16429/j.1009-7848.2021.03.012",

language = "繁体中文",

volume = "21",

pages = "102--106",

journal = "Journal of Chinese Institute of Food Science and Technology",

issn = "1009-7848",

publisher = "Chinese Institute of Food Science and Technology",

number = "3",

}

TY - JOUR

T1 - 牛初乳中抗高血压因子对成年大鼠心肌细胞电压依懒性钙通道的影响

AU - Teng, Gang

AU - Ren, Haowei

AU - Zhao, Tianyu

AU - Shang, Jiaqi

AU - Liu, Ning

PY - 2021/3/31

Y1 - 2021/3/31

N2 - Objective: To observe the effect of anti-hypertensive factor(AFBC) in bovine colostrum on the intracellular free calcium concentration ([Ca2+]i) induced by potassium chloride in adult rat cardiomyocytes, the possible mechanism of inhibiting myocardial contraction in rats was investigated. Methods: Using fluorescent properties Fura-2/AM at freshly isolated rat ventricular myocytes. Results: 0.5 mg/mL AFBC had no significant effect on resting myocardisl cells [Ca2+]i, but could depress the increase of ventricular myocytes [Ca2+]i induced by 50 mmol/L KCl. Conclusion: AFBC can block the voltage-dependent calcium channel of ventricular myocytes in adult rat.

AB - Objective: To observe the effect of anti-hypertensive factor(AFBC) in bovine colostrum on the intracellular free calcium concentration ([Ca2+]i) induced by potassium chloride in adult rat cardiomyocytes, the possible mechanism of inhibiting myocardial contraction in rats was investigated. Methods: Using fluorescent properties Fura-2/AM at freshly isolated rat ventricular myocytes. Results: 0.5 mg/mL AFBC had no significant effect on resting myocardisl cells [Ca2+]i, but could depress the increase of ventricular myocytes [Ca2+]i induced by 50 mmol/L KCl. Conclusion: AFBC can block the voltage-dependent calcium channel of ventricular myocytes in adult rat.

KW - Antihypertensive

KW - Bovine colostrums

KW - Fura-2/AM

KW - Ventricular myocytes

KW - [Ca]

UR - https://www.scopus.com/pages/publications/85105415072

U2 - 10.16429/j.1009-7848.2021.03.012

DO - 10.16429/j.1009-7848.2021.03.012

M3 - 文章

AN - SCOPUS:85105415072

SN - 1009-7848

VL - 21

SP - 102

EP - 106

JO - Journal of Chinese Institute of Food Science and Technology

JF - Journal of Chinese Institute of Food Science and Technology

IS - 3

ER -

牛初乳中抗高血压因子对成年大鼠心肌细胞电压依懒性钙通道的影响

Abstract

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