含L-精氨酸和抗氧化物质组方的毒理学安全性研究

Yan Zhao; Baolu Zhao

doi:10.13995/j.cnki.11-1802/ts.023437

含L-精氨酸和抗氧化物质组方的毒理学安全性研究

Translated title of the contribution: Toxicological and safety research of a formula containing L-argarginine and antioxidants

Yan Zhao
, Baolu Zhao^*

^*Corresponding author for this work

Harbin Institute of Technology Weihai
CAS - Institute of Biophysics

Research output: Contribution to journal › Article › peer-review

Abstract

In order to explore the toxicological safety of L-arginine and antioxidant formulations, this paper focused on the toxicological evaluation of L-arginine, hawthorn extract, anemarrhena extract and astaxanthin formulations in accordance with " The Technical Specification for Inspection and Evaluation of Health Food "(2003 edition). Toxicology studies showed that the maximum tolerance dose to mice of for the formula was more than 20. 0 g/(kg · BW) . The results of Ames test, mouse bone marrow micronucleus test and mice sperm abnormality test were negative. For the 30 days oral toxicity test, the parameters were in the range of normal value. No significant toxic effects were found for the formula in this study. The formula is non-toxic, non-genotoxic, and does not cause mutations. Provide the scientific basis of toxicology for its clinical application and health food research and development.

Translated title of the contribution	Toxicological and safety research of a formula containing L-argarginine and antioxidants
Original language	Chinese (Traditional)
Pages (from-to)	108-113
Number of pages	6
Journal	Food and Fermentation Industries
Volume	46
Issue number	6
DOIs	https://doi.org/10.13995/j.cnki.11-1802/ts.023437
State	Published - 25 Mar 2020
Externally published	Yes

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title = "含L-精氨酸和抗氧化物质组方的毒理学安全性研究",

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keywords = "L-arginine, antioxidants, safety, toxicology",

author = "Yan Zhao and Baolu Zhao",

year = "2020",

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doi = "10.13995/j.cnki.11-1802/ts.023437",

language = "繁体中文",

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T1 - 含L-精氨酸和抗氧化物质组方的毒理学安全性研究

AU - Zhao, Yan

AU - Zhao, Baolu

PY - 2020/3/25

Y1 - 2020/3/25

N2 - In order to explore the toxicological safety of L-arginine and antioxidant formulations, this paper focused on the toxicological evaluation of L-arginine, hawthorn extract, anemarrhena extract and astaxanthin formulations in accordance with " The Technical Specification for Inspection and Evaluation of Health Food "(2003 edition). Toxicology studies showed that the maximum tolerance dose to mice of for the formula was more than 20. 0 g/(kg · BW) . The results of Ames test, mouse bone marrow micronucleus test and mice sperm abnormality test were negative. For the 30 days oral toxicity test, the parameters were in the range of normal value. No significant toxic effects were found for the formula in this study. The formula is non-toxic, non-genotoxic, and does not cause mutations. Provide the scientific basis of toxicology for its clinical application and health food research and development.

AB - In order to explore the toxicological safety of L-arginine and antioxidant formulations, this paper focused on the toxicological evaluation of L-arginine, hawthorn extract, anemarrhena extract and astaxanthin formulations in accordance with " The Technical Specification for Inspection and Evaluation of Health Food "(2003 edition). Toxicology studies showed that the maximum tolerance dose to mice of for the formula was more than 20. 0 g/(kg · BW) . The results of Ames test, mouse bone marrow micronucleus test and mice sperm abnormality test were negative. For the 30 days oral toxicity test, the parameters were in the range of normal value. No significant toxic effects were found for the formula in this study. The formula is non-toxic, non-genotoxic, and does not cause mutations. Provide the scientific basis of toxicology for its clinical application and health food research and development.

KW - L-arginine

KW - antioxidants

KW - safety

KW - toxicology

UR - https://www.scopus.com/pages/publications/85175829294

U2 - 10.13995/j.cnki.11-1802/ts.023437

DO - 10.13995/j.cnki.11-1802/ts.023437

M3 - 文章

AN - SCOPUS:85175829294

SN - 0253-990X

VL - 46

SP - 108

EP - 113

JO - Food and Fermentation Industries

JF - Food and Fermentation Industries

IS - 6

ER -

含L-精氨酸和抗氧化物质组方的毒理学安全性研究

Abstract

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