可见光促进三级胺α位C(sp³)-H键的胺化反应研究

Herein, the visible-light-induced α-C(sp³)-H amination reactions of tertiary amines were reported. By using readily available 1, 3-dioxoisoindolin-2-yl benzoate as precursor of N-radical and blue LEDs as green and sustainable energy source, the α-C(sp³)-H bonds of various N, N-dimethylaniline derivatives were aminated directly. Based on radical trapping experiment and documented literature, a mechanism involving radicals coupling was proposed. This method featured in mild reaction conditions and good functional group tolerance, which provides a simple and practical protocol to the modification of tertiary amines.